Title: Prevalence and Antibiotic Susceptibility Pattern of Staphylococcus aureus isolated from Blood Culture in a Teritiary Care Centre
Authors: Dr Sindhu Cugati, Dr Chitralekha Saikumar
DOI: https://dx.doi.org/10.18535/jmscr/v5i4.178
Abstract
Introduction: Bloodstream infections (BSIs) are associated with significant patient morbidity and mortality. Staphylococcus aureus (S. aureus) is a leading cause of bacteremia. Methicillin resistant Staphylococcus aureus (MRSA) is problematic, as the therapeutic outcome of MRSA infections is much worse compared to methicillin sensitive Staphylococcus aureus (MSSA).
Aim: To determine the prevalence &antibiotic susceptibility pattern of Staphylococcus aureus strains isolated from blood culture.
Methodology: This study was carried out from July 2016 to December 2016 in which 982 blood culture bottles were processed by automated blood culture system. A total of 161 strains of S. aureus isolated, were identified by standard biochemical methods. Antibiotic susceptibility testing was performed by Kirby Bauer Disk Diffusion method. Methicillin resistance was detected using cefoxitin (30 µg) disc.
Results: In our study 52.9% of isolates from blood culture were S. aureus, out of which 57.1% were MRSA & 42.9% were MSSA. In MRSA strains, the resistant rates to Penicillin, Erythromycin, Clindamycin, Cotrimoxazole, Ciprofloxacin & Gentamycin were 100%, 60%, 45%, 40%, 35% & 40% respectively. In MSSA strains, the resistance rates to thesame antibiotics were 86%, 14%, 11%, 9%, 10% & 13 % respectively. All the S. aureus strains were sensitive to Linezolid & Teicoplanin.
Conclusion: Indiscriminate and irrational use of antibiotics have led to the emergence of superbugs like MRSA. Information regarding prevalence & antibiotic susceptibility patterns of MRSA strains guide the cliniciansto initiate empirical therapy and will help in formulation of antibiotic policy.
Keywords: Bacteremia; Blood Culture; MRSA; MSSA; S. aureus.
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