Title: Effect of Oral Pregabalin on Hemodynamic Stress Response to Laryngoscopy and Endotracheal intubation
Authors: Dhanya P.R, Deepa Franklin
DOI: https://dx.doi.org/10.18535/jmscr/v5i4.153
Abstract
Background: Direct laryngoscopy and endotracheal intubation are potent stimuli that initiate a hemodynamic response leading to increase in heart rate and blood pressure. This response can be attenuated by appropriate premedication, smooth induction and rapid intubation. The present study evaluated the efficacy of oral pregabalin in attenuation of hemodynamic stress response.
Materials and Methods: A total of 60 patients belonging to ASA PS 1 and 2 categories were divided into two equal groups. Group I received pregabalin 150mg capsule and group II received placebo one hour prior to surgery and were assessed for preoperative sedation, hemodynamic changes after laryngoscopy and endotracheal intubation along with post-operative side effects.
Results: Pre-operative sedation levels were higher in group I and caused statistically significant reduction in heart rate and mean arterial pressure at 1,3,5 and 10 minutes after laryngoscopy and endotracheal intubation. The systolic blood pressure values recorded at 1, 3 and 5 minutes post intubation in the pregabalin group was significantly lower than that in the control group. Diastolic blood pressure recorded at 1 min after intubation was significantly lower than the control group, although no difference was observed at 3 and 5 minutes after intubation.
Conclusion: 150 mg of oral pregabalin administered one hour before surgery is a simple and safe method for the attenuation of the hemodynamic response to laryngoscopy and intubation.
Keywords: Hemodynamic response, intubation, laryngoscopy, pregabalin, sedation.
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