Title: Follicular Dendritic Cell Sarcoma in Colon: A Rare Case Report
Authors: Vishal Dhingra, Shabi Ahmed, Yamini Jindal, PA Singh, Prachi Nayak, Priya Singh, Vatsala Misra
DOI: https://dx.doi.org/10.18535/jmscr/v5i4.50
Abstract
Follicular dendritic cells are localized in germinal centers of lymphoid follicles and play an integral role in regulation of the germinal center reaction and present antigens to B cells. A 22 year male patient presented with a well-defined mass around splenic flexure. On resection cut surface was smooth, fleshy and tan. On microscopy large pleomorphic cells with vesicular nuclei and prominent nucleoli intermingled with mature lymphocytes were present. Three mitotic figures /10HPF were noted. IHC was positive for Vimentin, CD21, CD23. Based on histological appearance and immunoprofile of the tumor, the diagnosis of Follicular dendritic cell sarcoma was made.
Key words: FDCS, IHC, CD21, CD23.
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