Title: Artesunate Resistant Plasmodium Falciparum
Authors: Dr Tapan Biswas MD, Dr Tirtho Purakait MD, Dr Uttam Pandit MD
DOI: https://dx.doi.org/10.18535/jmscr/v5i4.48
Abstract
Malaria is a life-threatening disease caused by parasites that are transmitted to people through the bites of infected female Anopheles mosquitoes. WHO recommends artemisinin-based combination therapies (ACTs) for the treatment of uncomplicated malaria caused by P. falciparum. ACTs have been integral to the remarkable recent successes in global malaria control. However, P. falciparum resistance is now emerging to artemisinin having detected in five countries of the Greater Mekong Subregion: Cambodia, Laos, Myanmar, Thailand and Viet Nam. In India, it is also reported artesunate resistant Plasmodium falciparuum. We described a 22year male patient admitted with cerebral malaria caused by p. falciparum and found artisunate resistance case.
Keywords: Malaria; Plasmodium falciparum; Artisunate resistant.
References
1. WHO/ Malaria-Fact sheet-Updated December 2016
2. WHO | World Malaria Report -http://www.who.int/malaria/publications/world_malaria_report/en
3. WHO | Antimalarial drug resistance http://www.who.int/malaria/areas/drug_resistance/overview/en/
4. Clinical Case of Artesunate Resistant Plasmodium falciparum ...http://www.esciencecentral.org/journals/clinical-case-of-artesunate-resistant-plasmodium-falciparum-malaria-in-kolkata-a-first-report-2329-891X.10001
5. WHO | Q&A on artemisinin resistance-who.int/malaria/media/artemisinin_resistance_qa/en/
6. The ongoing battle against drug resistant malaria | Stories ...
www.yourgenome.org/stories/the-ongoing-battle-against-drug-resistant-malaria
7. October 2016 Status Report -Artemisinin and artemisinin-based combination therapy resistance -. Guideline for diagnosis and treatment of malaria in India (2009) Government of India.
8. Saha P, Guha SK, Das S, Mullick S, Ganguly S, et al. (2012) Comparative efficacy of artemisinin combination therapies (ACTs) in P. falciparum malaria and polymorphism of pf.ATpase 6, pfacrt. pfdhfr and pfdhps genes in tea gardens of Jalpaiguri district, India. Antimicrob. agents and Chemother 56: 2511-2517.
9. Das S, Chakraborty SP, Tripathy S, Hati A, Roy S (2012) Novel quadruple mutations in dihydropteroate synthase genes of Plasmodium falciparum in West Bengal, India. Trop Med Int Health 17: 1329-1334.