Title: Triggering Receptor Expressed on Myeloid Cells-1 and Clinical Disease Activity in Patient with SLE Nephritis 24 Months Follow-Up Study
Authors: Sami Abdulhakim, Salama Saad Abd Al Latif, Ashraf Abo Taleb, Khaled Elsyes, Mohammed Abdulraof Mohammed Ashraf Abdelmoniem
DOI: https://dx.doi.org/10.18535/jmscr/v5i4.31
Abstract
Objective: Is the TREM-1 can be used as a predictor of early disease activity or follow-up of a lupus patient.
SLE pathogenesis is a multifactorial disease, the Traditional biomarker used in an everyday assessment of SLE patients such as ANA, Anti-DNA, C3, C4, creatinine clearance, and kidney biopsy. TREM-1 is a member of the immunoglobulin super family with an established role in innate and adaptive immune response and possible role in SLE nephritis.
Methods: thirty-five SLE patients classified according to SLICC Revised Criteria for Diagnosis of SLE 2012 and 20 healthy control group. All patients underwent full clinical and lab assessment and kidney biopsy were taken through the study according to clinical assessment of SLE activity with consent taken. TREM-1 was done for all patient group at an early study and after 24 months of SLE disease activity.
Results: this results showed increased level of TREM-1 early and marked elevation at the end of the study and highly significant difference within the patients and between patient and study group P<0.05. There is a positive correlation between TREM-1 and renal biopsy and anti-DNA, C3, C4 SELENA score
Conclusion: TREM-1 can be used as biomarkers for monitoring and/or predicting SLE disease activity but, needs to be further investigated with large-scale multicenter trials. A combination of novel markers with conventional clinical parameters to enhance the sensitivity and specificity for the early prediction of renal disease/flares and prognosis in patient with lupus nephritis
Key Ward: TREM-1 and early lupus activity.
References
1. Brunner, H., Bennett, M., Mina, R., Suzuki, M., Petri, M., Kiani, A. et al. (2012) Association of noninvasively measured renal protein biomarkers with histologic features of lupus nephritis. Arthritis Rheum 64: 2687–2697.
2. Bombardier C, Gladman DD, Urowitz MB, et al. Derivation of the SLEDAI: a disease activity index for lupus patients. Arthritis Rheum. 1992;35(6):630-640
3. Ford JW, McVicar DW. (2009). TREM and TREM-like receptors in inflammation and disease. Curr Opin Immunol, 21(1), 38–46.
4. Iman H. Bassyouni, Samar Fawzi, Tamer A. Gheita, Rasha H. Bassyouni, Aml S. Nasr, Samah A. El Bakry Clinical Association of a Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) in Patients with Systemic Lupus Erythematosus Pages 38-47 Published online: 20 Sep 2016 A Journal of Molecular and Cellular Immunology
5. Jan J. Weening, Vivette D. D’agati, Melvin M. Schwartz, Surya V. Seshan, Charles E. Alpers, Gerald B. Appel, James E. Balow, Jan A. Bruijn, Terence Cook, Franco Ferrario, Agnes B. Fogo, Ellen M. Ginzler, Lee Hebert, Gary Hill, Prue Hill, J. Charles Jennette, Norella C. Kong, Philippe Lesavre, Michael Lockshin, Lai-Meng Looi, Hirofumi Makino, Luiz A. Moura, And Michio Nagata The classification of glomerulonephritis in systemic lupus erythematosus revisited Kidney International, Vol. 65 (2004), pp. 521–530
6. Kelly D. Smith: Toll-like receptors in kidney disease Curr Opin Nephrol Hypertens. 2009 May ; 18(3): 189–196. doi:10.1097
7. Kim J, Koh, J E. Lee, J. Park, H. Kim, E. Lee, G. Cecilia, A. Cotena, Y. Song Serum levels of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and pentraxin 3 (PTX3) as markers of infection in febrile patients with systemic lupus erythematosus Clinical and Experimental Rheumatology 2009; 27: 773-778.2009 Vol.27, N°5 - PI 0773, PF 0778
8. Larry J and Kricka D (1996): principles of immunochemical techniques. In Tietz fundamental of clinical chemistry. Editor Tiety. N. W. fourth edition, WB sounders company Philadelphia Ch. 10. Pp. 134-148.
9. Laurie Davis1, Yong Du2, Tianfu Wu3 and Chandra Mohan 4Triggering Receptor Expressed on Myeloid Cells 1 In Systemic Lupus Erythematosus 2013 ACR/ARHP Annual Meeting
10. Longxiang Su, Bingchao Han, Changting Liu, Liling Liang, Zhaoxu Jiang, Jie Deng, Peng Yan1, Yanhong Jia, Dan Feng and Lixin Xie Value of soluble TREM-1, procalcitonin, and C-reactive protein serum levels as biomarkers for detecting bacteremia among sepsis patients with new fever in intensive care units: a prospective cohort study BMC Infectious diseases 2012, 12:157 doi:10. 1186/1471-2334-12-157
11. Manderson, A., Botto, M. and Walport, M. (2004) The role of complement in the development of systemic lupus erythematosus. Annu Rev Immunol 22: 431–456.
12. Mok, C. “Prognostic factors in lupus nephritis,” Lupus, vol. 14, no. 1, pp. 39–44, 2005.
13. Petri M, Orbai AM, Alarcón GS, et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum 2012; 64:2677.
14. Rahman, A. and Isenberg, D. (2008) Systemic lupus erythematosus. N Engl J Med 358: 929–939.
15. Rossini Botev, Jean-Pierre Mallié, Cecilé Couchoud, Otto Schück, Jean-Pierre Fauvel, Jack F.M. Wetzels, Nelson Lee, Natale G. De Santo, and Massimo Cirillo: Estimating Glomerular Filtration Rate: Cockcroft–Gault and Modification of Diet in Renal Disease Formulas Compared to Renal Inulin Clearance. Clin J Am Soc Nephrol 2009 May; 4(5): 899-906.
16. Stock AD, Wen J, Putterman C. (2013). Neuropsychiatric lupus, the blood brain barrier, and the TWEAK/Fn14 pathway. Front Immunol, 4, 484.
17. Yair Molad1, Tania Kaptzan2, Assaf Monselise2, Michal Shalita-Chesner1, Elisheva Pokroy-Shapira2, Jaqueline Sulkes2, Yehudit Monselise2. Up-Regulation of Triggering Receptor Expressed on Myeloid Cells 1 (trem-1) in Systemic Lupus Erythematosus 2013 ACR/ARHP Annual Meeting
18. Yan-wei WU, Wei TANG, Jian-ping ZUO Toll-like receptors: potential targets for lupus treatment Acta Pharmacologica Sinica (2015) 36: 1395–1407; doi: 10.1038/aps.2015.91; published online 23 Nov 2015
19. Yong Du, Tianfu Wu, Xin J. Zhou, Laurie S. Davis, and Chandra Mohan Blockade of CD (TREM-1) Ameliorates Anti-GBM-Induced Nephritis Inflammation, Vol. 39, No. 3, June 2016 (2016).
20. Zhihong Yuan ,Mansoor AliSyed, Dipti Panchal, Myungsoo Joo, Marco Colonna, Mark Brantly, and Ruxana T. Sadikot: The Journal of Biological Chemistry VOL. 289, NO. 21, pp. 15118–15129, Triggering Receptor Expressed on Myeloid Cells1 (TREM-1) mediated Bcl-2 Induction Prolongs Macrophage Survival November 22, 2013, and Published, JBCP, April 7,2014.