Title: A Study on Serum Uric Acid and Proteinuria in Association with Diabetic Nephropathy among Type 2 Diabetic Patients in a Teritary Care Centre
Authors: Dr Beena Unnikrishnan, Dr Mookambika R .V, Dr Vishnu.G.Ashok
DOI: https://dx.doi.org/10.18535/jmscr/v5i4.19
Abstract
Background: Diabetes is the leading cause of end stage renal disease, adult-onset blindness, and non-traumatic lower limb amputations. Diabetic nephropathy (DN), is the leading cause of kidney diseases in patients starting renal replacement therapy and affects approximately 40% of type 1 and type 2 diabetic (T2D) patient). The pathogenesis of diabetic nephropathy include glycosylation of circulating and intrarenal proteins and abnormal intrarenalhemo dynamics. Recently various studies shows that level of serum uric acid was shown to be higher in diabetic patients with persistent macroalbumin
Aims & Objectives: To find out the association between serum uric acid and proteinuria level among type 2 diabetic patients attending a tertiary care centre.
Subjects and Methods: A cross sectional study was carried out in the General medicine outpatient department of a tertiary care Centre. Diabetic nephropathy patients of both gender with no significant body weight changes for at least 3 months aged 30-60 years before the study are included in the study and Patients with Family history of gout, with known gout , on chemotherapy and known cancer patients are excluded.
Results: Out of the 50 study participant’s majority are females (60%). Mean ± SE of serum creatinine was 0.88 ± 0.038 mg/dL, mean ± SE of serum uric acid was 4± 0.12 mg/dl, and mean ± SE of proteinuria was 382 ± 24.7 mg/day (median = 300.5 mg/day.
Conclusion: serum uric acid plays a a major pathological role in the development of diabetic nephropathy in type 2 diabetic mellitus patients
Keywords: Serum uric acid, Diabetic nephropathy, Diabetic mellitus.
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