Title: Distribution and effect of APO E genotype on plasma lipid in non-obese and obese in north Indian population
Authors: Rajesh Kumar Thakur, M Itagappa, GRK Rao, Saurabh Srivastava, Rachna Aggarwal
DOI: https://dx.doi.org/10.18535/jmscr/v5i3.204
Abstract
Introduction: Apolipo protein E (apo E) plays key role in lipid metabolism, obesity and accordingly in development of diabetes and coronary heart disease (CHD).
Methods: Apo E polymorphism was performed using polymerase chain reaction- restriction fragment length polymorphism in 80 non-obese and 80 obese patients was collected from northern India. Levels of lipids and glucose were determined in these subjects.
Results: The genotype and allele frequencies of APO E polymorphism in non-obese showed no significant statistical difference compared to obese patients. In obese group, the subjects with E4E4 genotype had significantly lower levels of HDL and higher levels of triglycerides, LDL, VLDL, HDL/LDL, TC/HDL and TG/HDL compared to E2E3/E3E3 genotype. E4 allelic carrier had significantly higher levels of LDL, Total cholesterol and LDL/HDL compared to non-carrier.
Conclusions: The APO E gene polymorphism is associated with altered plasma levels of HDL, LDL, VLDL and triglycerides in north Indian population.
Keywords: Obesity, Dyslipidemia, Genetic polymorphism, APO E gene polymorphism, lipid profile.
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