Title: Study of Umbilical Cord Blood Lipid Profile in Relation to Gestational Age and Neonatal Birth Weight
Authors: Lekha Mishra, R.A.Langade, Ankit Gupta, Raghunandan Reddy
DOI: https://dx.doi.org/10.18535/jmscr/v5i3.71
Abstract
BACKGROUND-Atherosclerotic cardiovascular disease is the major cause of death in adulthood and has become a significant problem in our society. Increasing awareness about the origin of the atherosclerosis in early life has renewed interest in determination of various lipid fractions in paediatric age group and it is well documented that atherosclerosis may originate during fetal period.
This study was undertaken with the aim to find out the correlation of gestational age and birth weight with cord blood lipid profile in neoantes.
OBJECTIVE- To estimate and compare the cord blood lipid profile in term and preterm neonates, small for gestational age(SGA) and appropriate for gestational age (AGA)neonates.
METHOD-It was a hospital based cross sectional observational study. Cord blood lipid profile of 150 neonates were studied at a tertiary care centre. After written and informed consent of parents cord blood was collected at birth and sent for lipid profile analysis. Lipid profile was compared between preterm and term neonates, SGA and AGA neonates. statistical analysis was done using unpaired t-test. p<0.05 was considered significant
RESULTS- A total of 150 neonates were studied of which 80 were term neonates and 70 were preterm. Among them 88 were AGA and 62 were SGA. Preterm neonates had higher values of TC (96.6±18.6), TG (80.03±16.36), LDL (53.66±1.04), compared to Term neonates and values were statistically significant (p<0.05). Cord blood Lipid profile values for TG (85.41±16.86) was significantly higher (P<0.05) and HDL (22.24±7.87) level was significantly lower (p<0.05) in the SGA neonates compared to AGA neonates
CONCLUSION-Preterm neonates had significantly higher cord lipid profile compared to term neonates. SGA neonates had significantly higher values of TGL and significantly lower values of HDL compared to AGA neonates. Cord lipid profile value does not have significant correlation with gender. Key words-lipid profile, small for gestational age, preterm.
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