Title: Comparative Study of Histology of Placenta in Normotensive and Hypertensive Cases
Authors: Susheela Rana, Yogesh Diwan, Randhir S Chauhan, Deepa Diwan, Ankur Gupta
DOI: https://dx.doi.org/10.18535/jmscr/v5i3.60
Abstract
Aim: Placenta is an organ of the vital importance for the continuation of a pregnancy and fetal nutrition. the present study was undertaken to to find out the morbid changes of the placenta of hypertensive mothers in comparison to normotensive mothers.
Material and Methods: One hundred and fifty placentae of hypertensive and normotensive mothers were obtained from the department of obstetrics and gynecology. The placentae were fixed in 10% formalin and sectioned at 1 cm interval keeping the foetal surface intact. Blocks prepared were then stained with haemotoxylin and eosin.
Results: 100 placentae were from normotensive subjects (mean age 25.6±4.0 years) and 50 belonged to hypertensive patients (mean age 25.12±3 years). The infarction was observed in 12% cases of normotensive to 70% cases in severe hypertension. 70% cases in severe hypertension had syncytial knots while 90% had calcification. Stromal fibrosis and hypovascularity also increases with the severity of hypertension and was seen 50% and 30% cases respectively in severe hypertension.
Conclusion: Hypertension during pregnancy induces syncytial knots, calcification, Stromal fibrosis, hypovascularity which compromise utero-placental blood flow and may significantly reduce the neonatal birth weight.
Keywords: Placenta; hypertension; birth weight.
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