Title: A New Dermocosmetic Balm for the Management of Xerosis: Results from A Non-Interventional, Non-Comparative, Prospective Multicenter Study
Authors: Floriane Gayraud, Michèle Sayag, Eric Jourdan
DOI: https://dx.doi.org/10.18535/jmscr/v5i3.36
Abstract
Introduction-Xerosis is a common skin condition affecting all skin types at all ages. However, itis somewhat more often observed in young children and the elderly.
Objective-To assess the safety and benefit of a dermocosmetic balm in the management of xerosis.
Methods-Non-interventional, non-comparative, prospective multicenter study conducted in xerosis subjects of at least 3 months of age. Clinical assessments included the investigator’s evaluation of local tolerance, xerosis signs and symptoms at Days0, 14 and 21, as well as the subject’s perception of improvement, satisfaction, and compliance.
Results- The mean age of the 1149 recruited subjects was 42.4±24.9 years. According to the investigators, 882 (76.8%) subjects hadsevere xerosis.
The local tolerance of SBT was excellent, with only 1% of the subjects reporting adverse events leading to withdrawal. All xerosis signs and symptoms had significantly (p < 0.0001) improved at all post-Day 0 visits, starting as early as Day 7.Xerosis had improved in 1127 (98.1%) subjects and in 864 (75.2%) subjects the disorder had completely disappeared.
Patient perception improved significantly (all p<0.0001) between Day 7 and Day 14/21 as well as between Day 14 and 21.In total, 1081 (94.1%) subjects rated the efficacy of the dermocosmetic excellent or good, and 1032 (91.2%) subjects were satisfied with the balm.
Conclusion-The local tolerance of the balm is excellent. The balm provides good clinical benefit in the management of xerosis.
Keywords- Balm, dry skin, SBT complex, skin barrier, xerosis.
References
1. Pons-Guiraud A. Dry skin in dermatology: a complex physiopathology. J Eur Acad Dermatol Venereol. 2007;21 Suppl 2:1-4. DOI: 10.1111/j.1468-3083.2007.02379.x
2. Al-Nuaimi Y, Sherratt MJ, Griffiths CE. Skin health in older age. Maturitas. 2014;79(3):256-64. DOI: 10.1016/j.maturitas.2014.08.005
3. Blume-Peytavi U, Tan J, Tennstedt D, Boralevi F, Fabbrocini G, Torrelo A, et al. Fragility of epidermis in newborns, children and adolescents. J Eur Acad Dermatol Venereol. 2016;30 Suppl 4:3-56.doi: 10.1111/jdv.13636.
4. Saint-Leger D, Francois AM, Leveque JL, Stoudemayer TJ, Kligman AM, Grove G. Stratum corneum lipids in skin xerosis. Dermatologica. 1989;178(3):151-5.
5. White-Chu EF, Reddy M. Dry skin in the elderly: complexities of a common problem. Clin Dermatol. 2011;29(1):37-42. DOI: 10.1016/j.clindermatol. 2010.07.005
6. Al-Ghazzewi FH, Tester RF. Impact of prebiotics and probiotics on skin health. Benef Microbes. 2014;5(2):99-107. DOI: 10.3920/BM2013.0040
7. Zouboulis CC, Boschnakow A. Chronological ageing and photoageing of the human sebaceous gland. Clin Exp Dermatol. 2001;26(7):600-7.
8. Hoffman L, Subramanyan K, Johnson AW, Tharp MD. Benefits of an emollient body wash for patients with chronic winter dry skin. Dermatol Ther. 2008;21(5):416-21. DOI: 10.1111/j.1529-8019.2008.00225.x
9. Wolf R, Parish LC. Effect of soaps and detergents on epidermal barrier function. Clin Dermatol. 2012;30(3):297-300. DOI: 10.1016/j.clindermatol.2011.08.021
10. Ward JR, Bernhard JD. Willan's itch and other causes of pruritus in the elderly. Int J Dermatol. 2005;44(4):267-73. DOI: 10.1111/j.1365-4632.2004.02553.x
11. Valdes-Rodriguez R, Stull C, Yosipovitch G. Chronic pruritus in the elderly: pathophysiology, diagnosis and manage-ment. Drugs Aging. 2015;32(3):201-15. DOI: 10.1007/s40266-015-0246-0
12. Stander S, Weisshaar E, Mettang T, Szepietowski JC, Carstens E, Ikoma A, et al. Clinical classification of itch: a position paper of the International Forum for the Study of Itch. Acta Derm Venereol. 2007;87(4):291-4. DOI: 10.2340/00015555-0305
13. Humbert P, Dreno B, Krutmann J, Luger TA, Triller R, Meaume S, et al. Recommendations for managing cutaneous disorders associated with advancing age. Clin Interv Aging. 2016;11:141-8. DOI: 10.2147/CIA.S96232
14. Marks R. Actions and effects of emollients. New York. Georg Thieme Verlag S, 2002. 12-23.
15. Loden M. The clinical benefit of moisturizers. J Eur Acad Dermatol Venereol. 2005;19(6):672-88; quiz 86-7. DOI: 10.1111/j.1468-3083.2005.01326.x
16. Lodén M. Role of Topical Emollients and Moisturizers in the Treatment of Dry Skin Barrier Disorders. American Journal of Clinical Dermatology. 2003;4(11):771-88.
17. Gayraud F, Sayag M, Jourdan E. Efficacy and tolerance assessment of a new type of dermocosmetic in infants and children with moderate atopic dermatitis. J Cosmet Dermatol. 2015;14(2):107-12. DOI: 10.1111/jocd.12145.