Title: Vitamin D and Stroke: A Comparative Study to Risk Factors and Stroke Type
Authors: Abeer A.Tony, Effat A E.Tony, Emad F. Kholef, Wafaa S Mohammed
DOI: https://dx.doi.org/10.18535/jmscr/v5i3.18
Abstract
Background: Stroke remains one of the most devastating neurological diseases, often causing death, or gross physical impairment. Vitamin D deficiency has been reported to contribute to the risk of cardiovascular disease especially stroke. Thus, our study was designed to examine the relationship between serum 25 (OH) D levels and outcomes after stroke either ischemic or hemorrhagic.
Methods: Fifty patients with first–ever acute stroke (25 patients with intracerebal hemorrhage and 25 patients with ischemic infarction). All participants were subjected to full clinical and neurological examination. Brain imaging was performed. Blood samples were drawn for assessment of serum 25-hydroxy vitamin D and parathormone.
Results: The Majority (84% and 76% respectively) of our studied patients with acute stroke had insufficient levels of vitamin D (˂ 50 nmol/L ) with more reduction in patients with acute ischemic infarction than hemorrhagic cases (28.72 ± 22.45 versus 38.49 ± 24.68 in group I and group II respectively), but with no statistical significance differences between both groups. There was an association between vitamin D levels, severity of stroke and functional outcome in patients with intracerebral hemorrhage but not in patients with ischemic stroke. In dead patients with intracerebal hemorrhage, an insufficient median vitamin D level was noticeable.
Conclusion: Vitamin D insufficiency may bear an association with acute stroke and its prevalent risk factors with a highest association between low 25(OH)D levels and risk of incident hemorrhagic stroke among people in Upper Egypt.
Keywords: Acute stroke, Scandinavian Stroke Scale (SSS), Modified Rankin Scale (mRS), Serum 25-hydroxyvitamin D, Parathormone (PTH).
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