Title: Early Onset Neonatal Sepsis in a Tertiary Care Centre
Authors: Dr Rohitha .S .Chandra, Dr Lancy. J, Dr Lathika Nayar
DOI: https://dx.doi.org/10.18535/jmscr/v5i2.68
Abstract
Sepsis prevails to be a major threat for neonates. Neonatal sepsis is an important cause of mortality and morbidity in neonatal intensive care units. It is responsible for 30-50% of the total deaths in developing countries. One year study was conducted in the Dept of microbiology, Govt. medical college, Thrissur, Kerala from July 2012 to June 2013 to find out the different species of bacteria causing sepsis in neonates and the antibiotic susceptibility pattern of the isolates. A total no of 230 blood samples were collected from neonates with clinical signs and symptoms of sepsis admitted within 72 hours of life in the newborn nursery of New Medical College Hospital, Thrissur. Culture positivity was 30% and the predominant species of bacteria isolated are staphylococcus aureus [34.8%] and Klebsiella pneumoniae [27.33%], Acinetobacter baumannii [4.35%]. CRP was positive in 68% of cases. Initial empirical therapy with cefazolin and Amikacin was given followed by administration of appropriate antibiotics based on antibiotic susceptibility pattern. Case fatality rate was14.3% in this study.
Keywords: sepsis, antibiotic susceptibility testing.
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