Title: Various Aspects of Plateletpheresis Procedure and Uses of Single Donor Platelet at a Tertiary Care Hospital
Authors: Dharmesh Chandra Sharma, Sachin Singhal, Arun Jain, Anita Arya, A. S. Tomar, Poonam Woike, Rajesh Gaur
DOI: https://dx.doi.org/10.18535/jmscr/v5i2.60
Abstract
Abstract
Background: Transfusion services are aimed to provide only those components which patients require and keep the rest for others. Plateletpheresis is a technique performed on donors where platelet is separated ex vivo and remainder of the blood is returned to the donor. Platelet transfusion is critical due to lack of alternative; and therefore should be used rationally.
Aim: Present study is designed to evaluate Plateletpheresis procedure and uses of Single Donor Platelets (SDP) at our institute.
Materials and Methods: A 5 years study was carried out from 1st January 2012 to 31st December 2016 at a tertiary care centre where 1120 Plateletpheresis were conducted to prepare Single Donor Platelets (SDP) and transfused to 768 patients. Data were collected, compiled and compared statistically by frequency distribution and percentage proportion. Chi-square (χ2) test was applied to know the statistically significant difference (p value) of the data.
Results: An 1120 SDP were transfused to 768 patients with an average of 1.46 transfusions/ patient. An average age of donors was 32.30± SD6.84 years and Male: female ratio was 98.4:1.6. The average pre and post donation platelets/cumm of donors was 289.96x103± SD13.9x103 and 244.86x103± SD10.5x103 respectively and an average yield of SDP was 3.20x1011± SD1.86. Out of 1120 SDP transfusions given, clinically belonged to; dengue 64.1%, malaria 9.0%, malignancy 7.9%, thrombocytopenia due to unknown cause 5.0%, aplastic anaemia 2.1% , ITP 1.0%, liver disorders1.0%, neurosurgical0.9%, active bleeding 0.8%, miscellaneous 0.7% and vitiligo-0.5%. An average increment of platelets in the patients was 36.13x103 ± SD9.35x103/cumm. Out of 1120 transfusions, therapeutic were 1029(85.75%) where as prophylactic were 91(14.25%) (p=0.000003). Rationality of transfusions was 84% (p=0.000003). Adverse events during the Plateletpheresis procedures was 0.8% (p=0.000004).
Conclusions: A better rationality of SDP 84% in the study was observed. SDP should be used rationally and scientifically as per proven criteria because it has no alternative.
Keywords: Plateletpheresis, Single Donor Platelets, Donor, Rationality.
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