Title: Randomized comparative study of Intrathecal Sufentanil and Fentanyl combined with Lignocaine for Caesarean Section
Authors: Dr Yashwant Dhawle, Dr Rajkumar Ahirwal, Dr Deepesh Gupta
DOI: https://dx.doi.org/10.18535/jmscr/v5i2.33
Abstract
Aims and Objectives: To compare safety and efficacy of sufentanil and fentanyl in combination with lignocaine for caesarean section
Materials and Methods: A randomized comparative study was done on 50 parturient patients, divided into 2 group viz. Group I (12.5 mcg of fentanyl, 1.5 ml lignocaine 5% heavy 70mg) and Group II (5 mcg of sufentanil, 1.5 ml lignocaine 5% heavy 70mg) at Gandhi Medical College, Bhopal. Vital signs, sensory level, motor block and side effects were observed every 5 minute for first 30 minute and then every 15 minute till the completion of surgery.
Results: The duration of effective analgesia was significantly longer in Group II (268.4+26.384 min) compared to Group I (154.6+16.057 min) (p<0.05). Nausea and vomiting was observed in 4% patients in Group I whereas in Group II none of the patients showed nausea and vomiting. Pruritus was the significant side effect in Group II (48%) as compared to Group I (12%) (p<0.05).
Conclusion: Sufentanil provided significant longer duration of analgesia compared to fentanyl with better protection against nausea and vomiting.
Keywords: caesarean section, sufentanil, fentanyl, spinal anesthesia.
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