Title: Biochemical Parameters in Acute Myocardial Infarction with or Without Co-Morbidities
Authors: H. V. More, K. N. Pujari*, S. P. Jadkar, C. G. Patil
DOI: https://dx.doi.org/10.18535/jmscr/v5i2.11
Abstract
Acute myocardial infarction is one of the most common cause of death and one of the most frequent causes of hospitalization. Acute Myocardial Infarction occurs when there is an imbalance between supply and demand for oxygen in the heart muscle resulting in injury and eventual death of muscle cells. Various risk factors for acute myocardial infarction have been reported, including age, family history, smoking, serum cholesterol, diabetes and hypertension.
The present study was planned to measure oxidative stress markers as malondialdehyde as lipid peroxidation product and serum lipids such as total cholesterol, triglycerides, low density lipoprotein- cholesterol and high density lipoprotein- cholesterol in acute myocardial infarction with and without co-morbidities. Study includes 140 patients with acute myocardial infarction and 50 normal healthy control. The data were evaluated statistically. We found significantly increase in serum malondialdehyde (p<0.05) in patients as compared to control. Whereas highly significant increase in total cholesterol, triglycerides and low density lipoprotein- cholesterol (p<0.001) and significantly decreased high density lipoprotein- cholesterol (p<0.001) in patients as compared to control.
Our study revealed that myocardial infarction patients have elevated levels of serum lipid peroxidation product, total cholesterol, triacylglycerol and low density lipoprotein cholesterol and reduced high density lipoprotein in patients as compared to healthy subjects. High concentration of serum oxidative stress marker and lipids may strongly associated with the risk for coronary heart disease.
Key Words: Acute myocardial infarction, Lipid peroxidation, Triacylglycerol.
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