Title: Vitamin D Status, Insulin Resistance and Arterial Stiffness in Normal Healthy Subjects
Authors: Dr B.Sowjanya, Dr P.Ramamohan , Ms. P.Manvita, Mr D.Balakrishna
DOI: https://dx.doi.org/10.18535/jmscr/v5i1.145
Abstract
Vitamin D deficiency is common worldwide. Presence of vitamin D receptors on various tissues, explains its diversity of actions. Reduced levels of vitamin D is associated with insulin resistance (IR), diabetes, arterial stiffness and Cardio vascular disease (CVD) risk. This study was done to find out the association between hypovitaminosis D, IR and arterial stiffness. 50 normal healthy individuals, between 18 – 60 yrs of age (males & females ) were selected randomly, as study subjects . Blood pressure was recorded by sphygmomanometer. Fasting plasma and serum samples were collected for estimating Glucose, Total cholesterol, triglycerides , Insulin, 25 (OH) D, Insulin resistance calculated by HOMAIR .Arterial stiffness was measured by Sphygmo Cor analyser. Indices of arterial stiffness were Augmentation Index (AIx), Pulse wave velocity (PWV), Sub Endocardial Viability ratio (SEVR). The subjects were divided into 2 groups based on 25(OH) D levels. group 1 (</= 20 ng/ml ) , group 2 (>20ng/ml). All the parameters were compared between the groups. Statistical analysis was done by Students t test, Pearson’s correlation. 58% of the subjects were having Vitamin D deficiency. p value was significant for iPTH ( 0.03) and AIx (0.02). Inverse correlation was found between 25(OH) D and HOMIR (r = - 0.134). Our study concludes that vitamin D deficiency is common in normal healthy individuals. Hypovitaminosis D may lead to increased arterial stiffness & IR which will increase the future risk for CAD. Supplementation with Vitamin D may be beneficial for preventing CAD.
Keywords: Vitamin D, HOMAIR, Augmentation Index, iPTH.
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