Title: Significance of Platelet Parameters and Troponin T in Patients with Acute Coronary Syndrome
Authors: Dr G. Nataraju, Dr S.A.K. Adil, Dr R.K. Divya
DOI: https://dx.doi.org/10.18535/jmscr/v5i1.140
Abstract
Background: Coronary heart disease (CHD) is among the top five causes of morbidity worldwide, and manifests as acute coronary syndrome (ACS). Identifying risk factors for acute coronary syndrome (ACS) is important for both diagnostic and prognostic purpose. It is postulated that individuals with a large platelets are more predisposed to occluding thrombi in coronary vessels. Larger platelets are enzymatically and metabolically more active and have a higher potential thrombotic ability as compared with smaller platelets. Recently Cardiac markers are used in the diagnosis and risk stratification of patients with chest pain and suspected acute coronary syndrome (ACS). The cardiac troponins, namely TroponinT in particular, have become the cardiac marker of choice for patients with ACS.
Objectives: The aim of this study is to investigate whether there is an association of platelet indices and cardiac Troponin T with acute coronary syndrome and the significance of these parameters in the diagnostic workup of ACS.
Method: A descriptive study was done in Sri Jayadeva Institute of Cardiac science and Research (SJICSR), Mysore. A total of 100 patients admitted with diagnosis of ACS during the period January-June2016 were studied These patients were subjected to investigations of complete haemogram and Troponin T as routine procedure at the time of admission as they were clinically suspected as suffering from ACS.
Results: The study revealed that majority of patients were males(72%), the major age group affected were in the age of 41-50yrs and the mean values of Platelet Indices were MPV= 7.76 fl, PDW= 12.2%, Pct = 0.16% and Platelet Count = 2.53lacs. The mean value of Troponin T with respect to gender was 0.8ng/ml in males and 0.61ng/ml in females.
Conclusion: Mean Platelet Volume was not found to be a risk factor for Acute Coronary syndrome in our study. But Troponin T can be considered as a prognostic marker in patients with acute coronary syndrome.
Keywords: Acute coronary syndrome, Platelet Parameters, Troponin T.
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