Title: Immunohistochemistry in 169 Cases of Pituitary Adenoma
Authors: Lionel Rohit Mathew, S. Annapurneswari, V. S. Mallikarjuna
DOI: https://dx.doi.org/10.18535/jmscr/v5i1.106
Abstract
Aims and Objectives
To study the morphological and immunohisto-chemical profile of Pituitary Adenomas in relation to determination of cell differentiation & classification, clinical features, radiological features and biochemical data.
Introduction
The Human Pituitary Gland, despite being a small bean-shaped organ, is the commander of the major endocrine glands in the body. It exerts control over virtually every system and is located intracranially, close to areas of higher function of the Central Nervous System.
It is therefore, not surprising, for a Pituitary Adenoma, the most common tumour arising from it, to present with a wide range of symptoms that challenge clinicians of various specialties, who must assemble all the information they can obtain, with an open mind, to arrive at the diagnosis.
Materials and Methods
The study was performed in the Department of Histopathology, Apollo Specialty Hospital, Chennai. 172 cases of Pituitary Adenoma was collected over a period of three years (1st January 2007 to 31st December 2009). Of these, 169 cases were included in our study.
References
1. Robert Y. Osamura, Hanako Kajiya, Mao Takei et al. Pathology Of The Human Pituitary Adenomas Histochem Cell Biol (2008) 130: 495-507
2. R. Yoshiyuki Osamura, Shigeyuki Tahara, Reiko Kurotani, et al. Contributions of Immunohistochemistry and In Situ Hybridization to the Functional Analysis of Pituitary Adenomas, J Histochem Cytochem 2000; 48:445–458,
3. E. Horvath, K. Kovacs, R. V. Lloyd et al, Tumours Of The Pituitary Gland In: World Health Organization Classification of Tumours – Pathology and Genetics of Tumours Of Endocrine Organs 2004 pp 9-48.
4. J M Bilbao. Pituitary Gland. In: Juan Rosai, editor. Rosai and Ackerman's Surgical Pathology 2004 9th ed. pp: 2683 - 2712
5. M. Beatrix S. Lopes. Tumors of the Pituitary Gland. In : C D M Fletcher, Diagnostic Histopathology Of Tumours 3rd ed, 2007, Massachussets, Churchill Livingstone, pp 971 – 996.
6. B. W. Scheithauer , P. C. Burger, F. S. Vogel, Surgical Pathology Of The Nervous System And Its Coverings, 4th ed, 2004, Churchill Livingstone, PA, USA pp 437 -498.
7. B. W. Scheithauer, The Pituitary and Sellar Region, In: Stacey E. Mills Sternberg’s Diagnostic Surgical Pathology 4th Edn, 2004, Lippincott Williams and Wilkins, PA, USA, pp 521 – 556.
8. Disorders Of The Anterior Lobe of Pituitary, In: David Lowe, James Underwood, Recent Advances in Histopathology 19; pp1-13.
9. Wolfgang Saeger, Dieter K Lüdecke, Michael Buchfelder et al. Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry. European Journal of Endocrinology 156: 203–216.
10. Raymond V. Randall, Bernd W. Scheithauer, Kalman Kovac. Pituitary Adenomas: Historic Considerations In: Kamal Thapar Diagnosis and Management of Pituitary Tumours . New Jersey: Humana Press 2001. pp 1-12.
11. Isa M. Hussaini, Christy Trotter, Yunge Zhao et al. Matrix Metalloproteinase-9 Is Differentially Expressed in Nonfunct-ioning Invasive and Noninvasive Pituitary Adenomas and Increases Invasion in Human Pituitary Adenoma Cell Line. Am J Pathol 2007, 170:356–365.
12. E. Horvath, K. Kovacs. Gonadotroph Adenomas of the Human Pituitary: Sex-Related Fine-Structural Dichotomy; A Histologic, Immunocytochemical, and Electron-Microscopic Study of 30 Tumors; Am J Pathol 1984, 117:429-440
13. Katsuya Umeoka, Naoko Sanno, R Yoshiyuki Osamura, et al. Expression of GATA-2 in Human Pituitary Adenomas Mod Pathol 2002;15(1):11–17
14. Zhi Rong Qian, Chiun Chei Li, Hiroyuki Yamasaki,, et al, Role of E-Cadherin, α-, β-, and γ-Catenins, and p120 (Cell Adhesion Molecules) in Prolactinoma Behavior, Mod Pathol 2002;15(12):1357–1365.
15. Marek Pawlikowski, Anna Gruszka, Maciej Radek et al, Chromogranin A in pituitary adenomas: immunohistochemical detection and plasma Concentrations, Folia Histchemica et Cytobiologica, Vol. 42, No. 4, 2004, pp. 245-247.
16. Oyama K., Sanno N., Teramoto A. et al. Expression of Neuro D1 in Human Normal Pituitaries and Pituitary Adenomas, Mod Pathol 2001;14(9):892–899.
17. Heaney AP, Fernando M, Melmed S: PPAR-γ receptor ligands: novel therapy for pituitary adenomas, J. Clin. Invest. 2003 111:1381–1388.
18. Pawlikowski M, Kunert-Radek J, Radek M.: Plurihormonality of Pituitary Adenomas in light of Immunohistoc-hemical Studies, Endokrynol Pol 2010; 61 (1): 63-66.
19. M. L. C. R. Cury, J. C. Fernandes, H. R. Machado, L. L. Elias, et al: Non-functioning pituitary adenomas: clinical feature, laboratorial and imaging assessment, therapeutic management and outcome; Arq Bras Endocrinol Metab. 2009;53/1
20. K Kovacs, E Horvath, S Vidal. Classification of pituitary adenomas Journal of Neuro-Oncology , 2001 54: 121–127.
21. T Ho, Y Hsu, T Ting et al, Plurihormonal Pituitary Adenomas: Immunostaining of all Pituitary Hormones is mandatory for Correct Classification, Histopathology 2001 Sep;39(3):310-319.