Title: Transdermal Patch: A Comprehensive Overview of Newer Drug Delivery System in Modern Medical Science
Authors: Dr Neelkanth Kote, Dr. Poornima B
DOI: https://dx.doi.org/10.18535/jmscr/v5i1.71
Abstract
Background: Oral route of drug administration has been the most common route of drug administration since the beginning of the therapeuticarea in medical science. However this route of drug administration fails at bypassing the first pass metabolism of the drug in liver with poor bio availability. Oral route of drug administration also fails in uncooperative /unconscious semiconscious / pediatric subjects. Transdermal patch, a new drug delivery system through skin to the parenteral circulation has been the most recently discussed topic in pharmacology and medicine as it is a noninvasive route of drug administration, delivered in a sustained / pre fixed dosage with no / extremely less first pass metabolism and better bio availability. Most importantly it can be used in semiconscious / unconscious & pediatric subjects without affecting their hemodynamics. The transdermal patches have many beneficial factors however they also come with some major drawbacks like varieties of formulation, design and quality of adhesiveness. This articles provides an insight of transdermal patch in terms of its mechanism of action, advantages, disadvantages and future scope of it in the medical science.
Keywords: drug, transdermal patch,Bioavailability.
References
1. Sachan R, Bajpai M. Transdermal Drug Delivery System: A Review. Int. J. Res. Dev. Pharm. L. Sci. Dec - Jan, 2013, Vol. 3, No.1, pp 748-765 ISSN: 2278-0238
2. Patel D, Chaudhary SA, Parmar B, et al. Transdermal Drug Delivery System: A Review. J Pharm Innov. 2012 Vol. 1 No. 4, pp 66-75 ISSN: 2277-7695
3. Available at: http://painrelief.co.in/tr-ansdermal-patches/types-of-tdp/. Accessed on: 28 Aug, 2016.
4. Raza R, Mittal A, Kumar P, et al. Approaches and Evaluation of Transdermal Drug Delivery System. Int. J. Drug Dev. & Res. Jan – Mar 2015, 7 (1): 222-233 ISSN 0975-9344 (approach 6)
5. Latheeshjlal L, Phanitejaswini P, Soujanya Y, et al. Int.J. PharmTech Res.2011,3(4) pp 2140-2148. (patch 4)
6. Arnold LE, Lindsay RL, López FA, et al. Treating Attention-Deficit/Hyperactivity Disorder With a Stimulant Transdermal Patch: The Clinical Art. Pediatrics, 120 (5):
7. Available at: http://www.businesswire.com/news/home/20120823006186/en/ORIGINAL-BUGPATCH-Full-Body-Mosquito-Bite-Protection. Accessed on: 28 Aug, 2016.
8. J. Ashok kumar, Nikhila Pullakhandam, S. Lakshmana Prabhu. Transdermal Drug delivery system: An overview. International Journal of Pharmaceutical Sciences and Review. Jul- August2010, Vol. 3 No. 2, pp 49-54 ISSN: 0976 -044X
9. Gaur PK, Mishra S, Purohit S, Dave K. Transdermal drug delivery system- A review. Asian Journal of Pharmaceutical and Clinical Research. 2009; 2:14-20.
10. Heather AE. Transdermal Drug Delivery: Penetration Enhancement Techniques. Current Drug Delivery. 2005; 2:23-33.
11. Transdermal drug delivery system of nicotin suitable for use in smoking cessation. Indian Journal of pharmaceu-tical sciences. 2006; 68:179-184.
12. Vyas SP, Khar RK. Targetted and controlled Drug Delivery Novel carrier system. 1st ed. CBS Publishers and distributors New Delhi; 2002; 411- 447.
13. Ghosh B, Preethi GB, Mishra R, Parcha V. Transdermal Delivery of Ibuprofen and Its Prodrugs by Passive Diffusion and Iontophoresis. Int J Pharm Pharm Sci. 2010; 2(1):79-85.