Title: Tubal Ectopic Pregnancy and Variation in Platelet Parameters: A Six Years Study in Rural Population of Central India
Authors: Pravin Sukhdevrao Chavhan, Bharat Umakant Patil, Nitin Mrigrajendra Gangane
DOI: https://dx.doi.org/10.18535/jmscr/v5i1.60
Abstract
OBJECTIVE: The aim of our study was evaluate alteration of various platelet parameters such as platelet count, mean platelet volume (MPV) and platelet distribution width (PDW) in tubal ectopic pregnancy in rural population of central India.
METHOD: This was a retrospective study carried out during period of January 2010 to December 2015. Total 107 cases of tubal ectopic pregnancy evaluated in comparison to same number of patient as a control. During this period hemoglobin level and platelet parameters (platelet count, MPV and PDW) were analyzed.
RESULT: In our study we found significant decrease in mean hemoglobin level. The platelet counts were not that much affected. There was significant decrease in MPV (p < 0.001) and increase in PDW (p = 0.012) as compared to control. We also compare these parameters in ruptured versus non-ruptured ectopic pregnancy in which once again we found statistically significant decrease in MPV(p < 0.001) and increase in PDW (p = 0.009).
CONCLUSION: This study was mostly focused on rural population of central India where the rapid diagnostic tests are sometimes are unavailable. Hence decrease in trend in MPV and increase in PDW can be used as a tool to diagnose ectopic pregnancy.
Keywords: Mean platelet volume, platelet distribution width, platelet parameters, Tubal ectopic pregnancy.
References
1. Shaw JLV, Dey SK, Critchley HOD, Horn AW. Current knowledge of the aetiology of human tubal ectopic pregnancy. Human Reproduction Update 2010:16(4):432-444.
2. Varma R, Gupta J. Tubal ectopic pregn-ancy. Clin Evid (Online) 2009: pii:I406.
3. Samiya Mufti. Shagufta Rather, Samina Mufti, Reyaz A Rangrez, Wasiqa Kepa. Analysis Of 114 Cases. Jk Practitioner 2012:17(4):20–23.
4. Jurkovic D, Wilkinson H. Diagnosis and management of ectopic pregnancy. Brit Med Journal 2011:342:d3397.
5. Murray H, Baakdah H, Bardell T, Tulandi T. Diagnosis and treatment of ectopic pregnancy. CMAJ2005:11 173(8):905–12
6. Sindos M, Togia A, Sergentanis TN, Kabagiannis A, Malamas F, Farfaras A, et al. Ruptured ectopic pregnancy: risk factors for a life-threatening condition. Arch Gynecol Obstet 2009:279(5):621–3.
7. Clark JF, Verly GP, Johnson HD. Pathogenesis of tubal pregnancy. J Natl Med Assoc 1982:74(8):785–8.
8. Rausch ME BK. Serum biomarkers for detecting ectopic pregnancy. Clin Obs Gynecol 2012:55(2):418–23.
9. Barnhart KT. Clinical practice. Ectopic pregnancy. N Engl J Med 2009:23; 361(4):379–87.
10. Wagner DD, Burger PC. Platelets in inflammation and thrombosis. Arterios-cler Thromb Vasc Biol 2003:4;23 (12): 2131–7.
11. Shetty SK SA. A clinical study of ectopic pregnancies in tertiary care hospital from Manglore, India. Innov J Med Heal Sci 2014: 4(1):305–9.
12. Vyas Priti & Vaidya Pratibha(2000) .Epidemiology, diagnosis and manage-ment of ectopic pregnancy-an analysis of 196 cases.
13. Gaddagi R CA. A Clinical Study of Ectopic Pregnancy. JCDR 2012:6:867–9.
14. Gupta R, Porwal S, Swarnkar M SN, P. M. Incidence, trends and risk factors for Ectopic Pregnancies in a tertiary care hospital of Rajasthan. JPBMS 2012:16(7):1–3.
15. Bachman EA, Barnhart K. Medical management of ectopic pregnancy: a comparison of regimens. Clin Obstet Gynecol 2012:55(2):440–7.
16. Cabar FR, Fettback PB, Pereira PP, Zugaib M. Serum markers in the diagnosis of tubal pregnancy. Clin (São Paulo, Brazil) 2008:63(5):701–8.
17. Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia. 2010:14 (1):28–32.
18. Dundar O, Yoruk P, Tutuncu L, Erikci AA, Muhcu M, Ergur AR, et al. Longitudinal study of platelet size changes in gestation and predictive power of elevated MPV in development of pre-eclampsia. Prenat Diagn. 2008:28 (11):1052–6.
19. Yuri Gasparyan A, Ayvazyan L, P. Mikhailidis D, D. Kitas G. Mean Platelet Volume: A Link Between Thrombosis and Inflammation? Curr Pharm Des. 2011:1; 17(1):47–58.