Title: Comparison of Hemodynamic Response to IV Dexmedetomidine and IV Clonidine in Spine Surgery under General Anaesthesia
Authors: Dr Rashmi Bengali, Dr Tushar Patil, Dr Rohini Pawar
DOI: https://dx.doi.org/10.18535/jmscr/v5i1.24
Abstract
AIMS: Alpha 2 agonist are popularly used as adjunct in general anaesthesia. A study was carried out to investigate the ability of intravenous Dexmedetomidine vs Clonidine to maintain hemodynamic response in spine surgery.
METHODS: 60 patients scheduled for spine surgery were randomized in two groups 0f 30 each. Group D-received 0.5µg/kg Dexmedetomidine IV diluted in 10ml of normal saline given slowly over 10 min. Group C –received 0.5µg/kg Clonidine IV diluted in 10 ml of normal saline given slowly over 10 min.
Hemodynamic parameter were recorded after 10 min of giving study drug. Observations of parameters were maintained at 2,5,10 min and carried out till 110 min of duration.
RESULTS: The demographic profile was comparable. The pressor response to laryngoscopy, intubation, surgery and extubation were effectively decreased with dexmedetomidine and was highly significant on comparison with clonidine (P<0.0001).
CONCLUSION: Dexmedetomidine is an excellent drug to maintain hemodynamic response to intubation as compared to clonidine in spine surgery ,and better in achieving adequate analgesia and anaesthesia perioperatively.
KEYWORDS: Spine surgery, Dexmedetomidine, Clonidine, General anaesthesia.
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