Title: Gastroprotective and Antioxidant Effect of Gloriosa Superba on Indomethacin-Induced Gastric Ulcers in Rats
Authors: Siddhi Ashokkumar Mehta Falguni, Mrs. Rachana D. Sarawade, Vishakha Trivedi, Ayyub Shaikh
DOI: http://dx.doi.org/10.18535/jmscr/v3i8.27
DIDS : 08.2015-XXXXXXX
Abstract
Gloriosa superba plant is well documented traditionally in Ayurvedic system of medicine and is used in treating many diseases. The present study was undertaken to evaluate the gastroprotective effect of Gloriosa superba tuber extract (GSTE) on rats at the dose of 110mg/kg body weight. Administration of test drug (110mg/kg) reduced gastric lesions as compared to Indomethacin (25 mg/kg) treated group. In vivo antioxidant levels were also evaluated. It was observed that administration of Indomethacin caused significant decrease in levels of SOD, GSH, GSHPx and increase in level of LPO. But reverse trend was seen in rats pre-treated with test drug, that is increase in levels of SOD, GSH, GSHPx and decrease in level of LPO. The results suggest that the gastroprotective activity of methanolic extract of Gloriosa superba tuber can be contributed to its constituents and antioxidant potential.
Keywords: Gloriosa superba, gastroprotective, antioxidant, antioxidant enzymes.
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