Title: Evaluation of Neuroprotective Activity of Bauhinia Variegata on Haloperidol Induced Catalepsy in Rats
Authors: Vishakha Rajesh Trivedi, Mrs.Rachana D. Sarawade, Siddhi Mehta, Ayyub Shaikh
DOI: http://dx.doi.org/10.18535/jmscr/v3i9.47
Abstract
An acetone soluble leaf extract from Bauhinia variegata was investigated for its neuroprotective effects in the haloperidol induced catalepsy rat model of the disease by measuring behavioural and biochemical parameters in the model. In rat model catalepsy was induced by administration of haloperidol (1 mg/kg, p.o) in wistar rats of either sex. A significant reduction in the catalepsy was observed in the drug treated groups when compared to the disease induced group. The biochemical parameters were Lipid peroxidation, Glutathione (GSH) , Glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were assessed in brain. Administration of haloperidol resulted in increased lipid peroxidation and decreased levels of antioxidant enzymes i.e GSH,GSH-Px and SOD. The study showed that the plant extract significantly decreased lipid peroxidation levels and increased antioxidant enzyme levels.
KEYWORDS: Bauhinia variegata, neuroprotective, antioxidant, antioxidant enzymes
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