Title: Spirometric Evaluation of Airflow Limitation In Diabetics
Authors: Nookala Sunil Kumar D.T.C.D, DNB, Gali Prakash Vignan Kumar M.D, Bhavana Grandhi M.D, Tajik Mohammed Shafi (PG), Jyothi P D.T.C.D
DOI: http://dx.doi.org/10.18535/jmscr/v3i10.48
Abstract
Background: Diabetes is a growing public health problem especially in India. The lung may be a target organ in diabetic subjects because of the presence of microvascular circulation and connective tissue. Non enzymatic glycosylation of connective tissue in chronic hyperglycemia leads to end organ damage and lung functions were reduced in diabetic subjects as compared to the normal subjects.
Aim: To assess the pulmonary function tests in diabetic subjects.
Materials and methods: An observational study was done over a period of one year in diabetic subjects. Pulmonary function tests were done and the glycemic status of all these subjects was assessed.
Results: Study population included 137subjects with female to male ratio of 1.17:1.0. Among men, 33 were smokers and remaining 30 were non smokers. The predominant pattern in all subjects was restrictive type. Siginificant p value was seen when the duration of diabetes was compared with FEV1/FVC.
Conclusion: Thus our study emphasizes the alteration of the lung functions with the duration of diabetes.
Keywords: Diabetes, Lung function tests.
References
1. Lamande M, Darnaine-Giraud V, Constans T. Diabetes in elderly patients. La Medicine en France. 2006; 54(3):99.
2. King H, Aubert RE, Herman WH: Global Burden of Diabetes, 1995–2025 (Prevalence, numerical estimates, and projections). Diabetes Care 1998; 21: 1414–1431
3. Bela Shah, Narender Kumar, Geetha Menon, Sarabjeet Khurana, Hardeep Kumar. Assessment of Burden of Non-Communicable Disease-Diabetes. A project supported by WHO India office.
4. Movahed, Mohammad-Reza, Hashem-zadeh, Mehrtash, Jamal, M Mazen Increased prevalence of Asthma in patients with Type II Diabetes mellitus. Chest 2006; 130: 160S-c
5. Jamal S. Rana, Murray A. Mittleman, Javed Sheikh, Frank B. Hu, JoAnn E. Manson, Graham A. Colditz, Frank E. Speizer, R. Graham Barrand Carlos A. Camargo. Chronic Obstructive Pulmonary Disease, Asthma, and Risk of Type 2 Diabetes in Women. Diabetes Care 2004; 27:2478-2484.
6. Baker, E H, Janaway, C H, Philips, B J, Brennan, A L, Baines, D L, Wood, D M, Jones, P W. Hyperglycaemia is associated with poor outcomes in patients admitted to hospital with acute exacerbations of chronic obstructive pulmonary disease. Thorax 2006; 61: 284-289
7. Robert E. Walter, Alexa Beiser, Rachel J. Givelber, George T. O'Connor and Daniel J. Gottlieb. Association between Glycemic State and Lung Function. The Framingham Heart Study. American Journal of Respiratory and Critical Care Medicine 2003; p167: 911-916.
8. Sunder Mudaliar, and Robert R. Henry. Inhaled Insulin in Patients with Asthma and Chronic Obstructive Pulmonary Disease Diabetes Technol Ther. 2007 June 9; 1:S83-92
9. Mori H et al Abnormalities in pulmonary function in patients with NIDDM. Internal Medicine 1992; 31; 189-193.
10. P. Lange, S.Groth, J.Kastrup, M. Appleyard, J. Jansen, P. Schnohr Diabetes Mellitus, plasma glucose & lung function in a cross-sectional population study Eur Resp J 1989, 2.14-19
11. Innocenti F, Fabbri A, Anichini R, Tuci S, Pettina G, Vannucci F, De Giorgio LA, Seghieri G: Indications of reduced pulmonary function in type 1 (insulin-dependent) diabetes mellitus. Diabetes Res Clin Pract 1994; 25:161–168.
12. Rosenecker J., Hofler R., Steinkamp G., Eichler I., Smaczny C., Ballmann M., Posselt HG., Bargon J., Von der Hardt H.: Diabetes mellitus in patients with cystic fibrosis: the impact of diabetes mellitus on pulmonary function and clinical outcome. Eur. J. Med. Res. 2001; 6(8): 345-50
13. SK Rajan, P Rajesh Prabhu, Madhu Sasidharan, Spirometric evaluation of type1 DM Abstract of paper presented at APICON 2003, JAPI Vol 50, 1529 December 2002