Title: A Case Report of two Chronic Myeloid Leukemia Patients in Chronic Phase Exhibiting IgVH Gene Rearrangement
Author: Asif Iqbal, Arijit Nag, Uttam Kumar Nath, Maitreyee Bhattacharyya
DOI: http://dx.doi.org/10.18535/jmscr/v3i10.13
Abstract
In CML-CP, 90% of patients present with ph chromosome as sole genetic abnormality in neoplastic cells. Among the additional cytogenetic abnormalities, loss of Y chromosome, trisomy 8, trisomy 19, other single chromosome/gene abnormalities and complex abnormalities with double ACAs were found in that order. Abnormalities involving 14q32 has not been found in literature describing CML-CP, and in limited number of studies have been shown to be exclusively found in lymphoid blast crisis. We are presenting two cases of Chronic myeloid leukemia here, who presented to us with IgVH rearrangement along with ph+ chromosome, and are in chronic phase without any haematological or molecular indication of progressive disease.
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