Title: Role of Adiponectin in Development and Progression of Diabetic Complications
Authors: Soher A. Mohammed Ismail, Ahmed Osman, Mustafa Abd El-Aziz M, Shaimaa Mohammed kamel, Iman A. Fahmy, Mohamed El Hefni, Safyea Mohamed Hussien
DOI: http://dx.doi.org/10.18535/jmscr/v3i12.50
Abstract
This study aimed to elucidate the role of adiponectin in evolution of microvascular complication of type 2 diabetes mellitus, in particular retinopathy and nephropathy.
In addition, we attempted to find a correlation between the serum levels of adiponectin and different parameters such as duration of diabetes, age, sex, glycemic state, insulin resistance, lipid profile and albumin-creatinine ratio in type 2 diabetic patients with retinopathy and nephropathy in order to understand more about these risk factors .
This study involved sixty diabetic patients with type 2 diabetes mellitus with or without micro vascular complications involving either retinal or renal vasculatures or both. These patients were recruited from the outpatient clinic (A written consent was obtained from each case included in the study according to the Ethical Committee Approval of the Research Institute of Ophthalmology (RIO), Giza, Egypt. In addition to fifteen healthy subjects were involved and served as reference group.
In addition to serum levels of adiponectin, routine diabetic diagnostic markers such as blood glucose levels, glycosylated Hb, insulin resistance, lipid profile, and kidney function tests were performed to all individuals included in the study.
Full ophthalmological assessment including Fundus Fluorescein Angiography and clinical examinations (blood pressure, search for lower limb oedema, pallor, renal mass, etc.) have done for each subject.
Data of this study revealed that the levels of serum adiponectin were decreased in patients with diabetic retinopathy while they were increased in patients with either diabetic nephropathy alone and to a lesser extent, in diabetic patients with nephropathy and retinopathy.
Serum adiponectin levels were found to be correlated with some parameters of lipid profile in patients with mixed conditions, a notion that highlight the role of adiponectin in the pathogenesis of microvascular complications of diabetes. Moreover, these results suggest that increased total serum adiponectin may predict coexistence of vascular endothelial dysfunction in diabetic nephropathy patients. Therefore, we recommended that adiponectin can be used as a prognostic marker for diabetic complications which will initiate a new era for the management of diabetes.
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