Title: A Study of Clinical and Biochemical Profiles of HIV Subjects in Owerri, Southeast Nigeria
Authors: Dr Ernest Ndukaife Anyabolu, Dr Innocent Ijezie Chukwuonye, Dr Arthur Ebelenna Anyabolu, Dr Okezie Enwere
DOI: http://dx.doi.org/10.18535/jmscr/v3i12.29
Abstract
Background and Objectives: The impact of Human immunodeficiency virus (HIV) infection is enormous globally. This study aimed at identifying aspects of clinical and laboratory profile of newly-diagnosed HIV subjects in Owerri, southeast, Nigeria.
Methodology: This was a cross-sectional, descriptive study involving 393 newly-diagnosed HIV subjects and 136 non-HIV, sex- and age-matched Control, consecutively recruited from an HIV clinic and an out-patient clinic of Federal Medical Center, Owerri. Bio-data and anthropometric data were collected. Relevant investigations were performed. Data were compared between HIV subjects and Control.
Results: The mean age of the HIV subjects was 39±11 years and Control 39±12 years. Female/male ratio was 3:1 in boththe HIV subjects and the Control. Mean waist circumference in male HIV subjects was significantly higher than mean WC in male non-HIV Control (p=0.013). Mean high density lipoprotein cholesterol, (p<0.001), serum creatinine, (p=O01), spot urine protein (SUP), (p=0.013), spot urine creatinine, p<0.001), spot urine osmolality, (p<0.001), 24-hour urine protein, (<0.001), 24-hour urine osmolality, (p<0.001), were significantly higher in the HIV subjects than the Control, whereas mean low density lipoprotein cholesterol (p<0.001), hemoglobin, spot urine creatinine/osmolality ratio (p<0.001), 24-hour urine creatinine/osmolality ratio, (p<0.001) were significantly lower in HIV subjects than the Control.
Conclusion: Abnormalities of serum creatinine, urine osmolality, urine protein and serum lipids are common among newly-diagnosed HIV subjects in southeast, Nigeria.
There is need to evaluate HIV patients, at inception, for dyslipidemia, anemia and renal damage.
Keywords: Clinical Characteristics, laboratory profile, HIV patients, Owerri, southeast, Nigeria
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