Title: Estimated Glomerular Filtration Rate (eGFR) in Healthy Kidney Donors
Authors: Sheetal LG, Lakshminarayana GR, Anil M, Rajesh R, George K, Unni VN
DOI: http://dx.doi.org/10.18535/jmscr/v4i1.39
Abstract
Introduction:This study was done to determine the range of Glomerular filtration rate (GFR) in healthy kidney donors, from Kerala.
Materials and Methods: This retrospective study was done by including all consecutive voluntary kidney donors, who underwent donor nephrectomy at Amrita Institute of Medical Sciences, Kochi, Kerala from 2001 to 2011. The GFR was assessed by 99mTc-diethylenetriamine pentaacetic acid (DTPA) renogram (GC Gates method) as part of protocol during preoperative evaluation. The GFR by DTPA method was compared to values obtained by four variable MDRD formula and Cockcroft-Gault formula (CGF).
Results: The mean age of the study population was 45.32 years (Range - 18 to 64 years) with 71.7 % being females. The majority of the donors were parents (54.78%) followed by siblings (33.04%) and spouses (12.17%). The eGFR in a healthy kidney donor ranged was 56 to 117 ml/min by 99mTc DTPA; GC Gates method. The mean eGFR were 82.89 (SD:22.46), 85.25 (SD:16.90), and 84.56 (SD:11.60) ml/min by CGF, MDRD and DTPA respectively. There was positive correlation in eGFR between methods used in the study. In donors with DTPA GFR ranging from 80-100 ml/min; there was no significant difference in mean eGFR between methods.
Conclusions: The mean eGFR of a kidney donor from India, was 84.56 (±11.60) ml/min, which is lower than the normal value of western population. In donors with DTPA GFR < 80 ml/min; MDRD and CGF methods overestimated GFR. In donors with DTPA GFR >100 ml/min; the CGF, MDRD methods underestimated the GFR.
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