Title: Relationship between Hyperuricemia, Hyperglycemia and Elevated Triglyceride Levels in Cardiometabolic Disorder
Authors: Neha Sharma, Rajkumari Rathore, Dr Purnima Dey Sarkar, Dr Anil Bidwai
DOI: http://dx.doi.org/10.18535/jmscr/v4i1.20
Abstract
Introduction: High levels of triglycerides and uric acid have each been reported to be independently associated with an elevated risk for coronary heart disease.(1,2)
However, it is less well established whether high levels or triglycerides or uric acid, per se, represent independent cardiovascular risk factors. Rather, both hypertriglyceridemia and hyperuricemia serve as biomarkers for increased coronary heart disease risk.
Materials and methods: We retrospectively analyzed results of serum uric acid, fasting plasma glucose (FPG) and triglyceride tests performed on the whole cohort of outpatient adults consecutively referred to our laboratory for routine blood testing for one year. This study included 150 cardiometabolic subjects aged 25 to 80 years. The body mass index (BMI), waist circumference, total and HDL cholesterol, serum triglycerides and serum uric acid were measured.
Results: Data were analyzed using student t-test, pearson’s coefficient and linear regression model. The prevalence of a serum uric acid level >0.42 mmol/L in men was 18.32% and the prevalence of a serum uric acid level >0.36 mmol/L was 15.9% in women. Serum uric acid was strongly related to serum triglycerides in men as well as in women (r = 0.255 in men and r = 0.254 in women, p < 0.001). Uric acid levels were also significantly associated but to a lesser degree with age, BMI and waist circumference. This study shows that serum uric acid is markedly associated with parameters of the metabolic syndrome, in particular serum triglycerides.
Conclusion: The mutual biological interrelationship observed between serum uric acid, hypertriglyceridemia and hyperglycemia raises the possibility of a potential pathogenetic overlap between these conditions.
Keywords: Cardiometabolic disease, Hyperuricemia, Hypertriglyceridemia, Hyperglycemia, Metabolic syndrome.
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