Title: Antiphospholipid Syndrome In Pregnancy
Authors: Dr Arati Nayak, Dr Arata Kumar Swain, Dr Pradipta Kumar Patel, Dr Harekrusna Dalai
DOI: http://dx.doi.org/10.18535/jmscr/v4i1.08
Abstract
The antiphospholipid syndrome (APS) is a multisystemic disease, characterized by venous or arterial thromboses, or certain obstetric complications, and the presence of antiphospholipid antibodies (APAs) (1-4).
Lupus anticoagulant (LA), anticardiolipin antibodies (aCL) and anti-beta 2 glycoprotein 1 (anti-β2GP1) antibodies are the main antibodies in this syndrome (1;2;) APS occurs in isolation as a primary APS in more than 50% of the cases, but can be associated with other autoimmune diseases, most often with systemic lupus erythemathosus (SLE). Twenty to 35% of women with SLE develop APS (6). APS occurs for the most part in young women of fertile age (7). The most characteristic feature of obstetrical APS is miscarriage, It occurs rarely in children, and only 12% of all APS occur after 50 years of age(8)
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